Chemical Compound

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Enzoyl peroxide is effective for reducing the number and severity of acne lesions. BPO has a bactericidal effect on Propionibacterium acnes bacteria associated with acne and does not induce antibiotic resistance.^[11][12] It may be combined with salicylic acid, sulfur, erythromycin or clindamycin (antibiotics), or adapalene (a synthetic retinoid). Two common combination drugs include benzoyl peroxide/clindamycin and adapalene/benzoyl peroxide, an unusual formulation considering most retinoids are deactivated by peroxides. Combination products such as benzoyl peroxide/clindamycin and benzoyl peroxide/salicylic acid appear to be slightly more effective than benzoyl peroxide alone for the treatment of acne lesions.^[12]

Benzoyl peroxide for acne treatment is typically applied to the affected areas in gel, cream, or liquid, in concentrations of 2.5% increasing through 5.0%, and up to 10%.^[11] No strong evidence supports the idea that higher concentrations of benzoyl peroxide are more effective than lower concentrations.^[11]

Benzoyl peroxide commonly causes initial dryness and sometimes irritation, although the skin develops tolerance after a week or so. A small percentage of people are much more sensitive to it and liable to suffer burning, itching, crusting, and possibly swelling.^[13] It is sensible to apply the lowest concentration and build up as appropriate. Once tolerance is achieved, increasing the quantity or concentration and gaining tolerance at a higher level may give better subsequent acne clearance.^[14] Irritation can also be reduced by avoiding harsh facial cleansers and wearing sunscreen prior to sun exposure.^[14]

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• Epoxy resins – to offer corrosion resistance, solvent and chemical resistance, hardness and adhesion.
• Textiles – to improve wool’s resistance to moths, prepare fibers for dyeing, impart wrinkle resistance and prepare anti-static agents and textile sizings.
• Papers, inks and dyes – to produce wet-strength paper sizing, special printing inks, textile print pastes, and ultimately paper and paperboard products that have improved printability, pigment retention, folding endurance and gloss.
• Ion exchange resins – to produce anion exchangers used to clean polluted air and water.
• Other applications that use EPI as a raw material include surface active agents used in cosmetics and shampoos; rubbers exhibiting resistance to extreme temperatures, fuel, oil and ozone for automotive and aircraft parts, seals and gaskets, and a myriad of other uses; and agricultural products such as insecticides, bactericides and fungicides.

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